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gene, differs from that of chimpanzees at two amino acids, hinting that changes to the human form may have had a hand in the evolution of language2. A team led by Schreiweis' colleague Svante Pbo discovered that the gene is identical in modern humans (Homo sapiens) and Neanderthals jordan shoes 5 for sale (Homo neanderthalensis), suggesting that the mutation appeared before these two human lineages diverged around 500,000 years ago3. Altered squeaksA few years ago, researchers at the MPI Leipzig engineered mice to make the human FOXP2 protein4. The 'humanized' mice were less air jordan 1 retro jeter intrepid explorers and, when separated from their mothers, pups produced altered ultrasonic squeaks compared to pups with the mouse version of FOXP2. Their brains, compared with those of normal mice, contained neurons with more and longer dendrites the tendrils that help neurons jordan 11 concord 2011 communicate with each other. Another difference was that cells in a brain region called the basal ganglia were quicker to become unresponsive after repeated electrical stimulation, a trait called 'long term depression' that is implicated in learning and memory. At the neuroscience kobe 6 shoes meeting, Schreiweis reported that mice with the human form of FOXP2 learn more quickly than ordinary mice. She challenged mice to solve a maze that involved turning either left or right to find a water reward. A visual clue, such as a star, along with the texture of the maze's jordan 4 for sale ebay surface, showed the correct direction to turn. After eight days of practice, mice with the human form of FOXP2 learnt to follow the clues to the water 70% of the time. Normal mice took an additional four days to reach this level. Schreiweis says that the human form of the gene air jordan flight club allowed mice to more quickly integrate the visual and tactile clues when learning to solve the maze. In humans, she says, the mutation to FOXP2 might have helped our species learn the complex muscle movements needed to form basic sounds and then combine these sounds into words kobe 8 shoes price malaysia and sentences. Another MPI team member, Ulrich Bornschein, presented work at the neuroscience meeting showing that the changes to brain circuitry that lead to quicker learning come about with just one of the two amino acid changes in the human form of FOXP2. The second mutation jordan shoes 1 for sale may do nothing. "That makes sense," says Genevieve Konopka, a neuroscientist at the University of Texas Southwestern Medical Center in Dallas, who also studies FOXP2. Carnivores, including dogs and wolves, independently evolved the other human FOXP2 mutation, with no obvious